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A BLASTp of MamA and MSMEG_3214 sequences against REBASE, a comprehensive database of information about restriction enzymes and DNA methyltransferases involved in restriction-modification [19], revealed that these genes encode for a predicted Type II N4-cytosine or N6-adenine DNA methyltransferase, and a predicted Type II restriction enzyme, annotated as M.Msms1ORF2534P and Msms1ORF2534P, respectively, and both are predicted to recognize the same palindromic sequence, CTCGAG

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